A rapid, all-in-one point-of-care test device that identifies a clinically significant acute respiratory infection and can differentiate viral from bacterial causes.
FebriDx produces a multiplexed result pattern combining C-reactive protein (CRP) and myxovirus resistance protein A (MxA).
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CRP is an acute phase inflammatory protein that is elevated in both viral and bacterial infections. Bacterial infection is a potent stimulus of marked CRP elevation. CRP is elevated within 4-6 hours of onset and is correlated with the severity of the infection. Normal CRP is less than 3 mg/L. It has been demonstrated that 38-56% of patients with viral acute respiratory infections (ARI) have CRP levels greater than 20 mg/L which may lead to unnecessary antibiotics being prescribed.
MxA is an intracellular blood protein that is stimulated by interferon (IFN) alpha/beta cells. IFN cells are induced by viruses and form an essential part of the immune system's defense against viral infections. MxA protein becomes elevated only in the presence of acute viral infections and not in bacterial infections.